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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73218EGFR D770_N771insY/BaF3

- 詳細(xì)內(nèi)容
CBP73218 | |
I. Introduction | |
Cell Line Name: | EGFR D770_N771insY/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). | |
III. Representative Data | |
1. WB of EGFR D770_N771insY/BaF3
| |
2. Anti-proliferation assay |