| 名稱 | PIK3CA p.R88Q Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10331 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | PIK3CA p.R88Q Reference Standard |
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電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10331PIK3CA p.R88Q Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10331 | |
| Format | Genomic DNA |
| Description | PIK3CA R88Q lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R88Q confers a gain of function to the Pik3ca protein as indicated by increased phosphorylation of downstream targets Akt and S6 (PMID: 18829572) and demonstrates increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785). |
| Technical Data | |
| DNA Change | c.263G>A |
| AA Change | p.R88Q |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | NM_006218.1 |
| Cosmic ID | COSM746 |
| Chr position(GRCh37) | chr3:178916876 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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