| 名稱 | BRAF p.L597R Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10240 |
| 報(bào)價 | 900 |
| 特點(diǎn) | BRAF p.L597R Reference Standard |
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Email： zhangxiangwen@cobioer.com
電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10240BRAF p.L597R Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10240 | |
| Format | Genomic DNA |
| Description | BRAF L597R lies within the protein kinase domain of the Braf protein (UniProt.org). L597R results in activation of Braf as indicated by increased phosphorylation of Mek and Erk in cell culture (PMID: 22798288, PMID: 26343582), is associated with Erk activation in a patient tumor sample (PMID: 23715574), and in one of two cell lines, increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785). |
| Technical Data | |
| DNA Change | c.1790T>G |
| AA Change | p.L597R |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000288602 |
| Cosmic ID | COSM471 |
| Chr position(GRCh37) | chr7:140453145 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
